MAFK anticorps (AA 1-156)

N° du produit ABIN7596043

L’anticorps Souris Monoclonal anti-MAFK a été validé pour WB et ELISA. Il convient pour détecter MAFK dans des échantillons de Humain.

Aperçu rapide pour MAFK anticorps (AA 1-156) (ABIN7596043)

Antigène: MAFK (Transcription Factor MafK (MAFK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAFK est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: AT2F7

Détail du produit anti-MAFK anticorps

Épitope: AA 1-156

Fonction: Human MafK antibody

Purification: Purified

Immunogène: Recombinant human MAFK (1-156aa) purified from E. coli

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Détails sur MAFK

Antigène: MAFK (Transcription Factor MafK (MAFK))

Autre désignation: MafK

Sujet: The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locuscontrol regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by thetranscription factor NFE2 (nuclear factor erythroid-2). NFE2 DNA-binding activity consists of aheterodimer containing an 18-kD Maf protein (MafF, MafG or MafK) and p45. Since Maf homodimers lack aputative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize amongthemselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger)basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerizewith Fos and may act as competitive repressors of the NF-E2 transcription factor. The MafK of Maf proteinsis primarily expressed during development in mesenchymal and hematopoietic cells and neurons.

NCBI Accession: NP_002351